Bryopsis Cure: My Battle With Bryopsis Using Fluconazole

Did Fluconazole Kill all of your Bryopsis?

  • Yes

  • No

  • I'm treating my tank with it now.

  • I love Bryopsis and I'm mad that everyone is killing it.


Results are only viewable after voting.

FDchase

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My tank is still fairly new. I originally thought I was getting hair algae. Every water change I would suck out what I could and it kept spreading. Found out it was bryopsis when I looked closer.
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Got some reef flux from BRS. At day 8 of treatment it’s almost completely gone. There are a couple tiny patches left.
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AustinJT

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The Poll In This Thread is For Bryopsis Only not GHA,Turf,Bubble Algae or any other Algae

The 2 week treatment is for Bryopsis algae. For GHA,turf algae and bubble algae it may take as long as 4-6 weeks to kill.

GHA,turf algae,bubble algae are different than Bryopsis algae. Bryopsis algae will not return if you kill all of the Bryopsis cells unless you reintroduce it into your tank. The others can/will return once you stop treating your tank and perform water changes to remove the meds. Fluconazole doesn't change the conditions in your tank that allowed for the algae growth in the first place. Removing the meds just sends your tank back to the same conditons that you had before the treatment. If your using Fluconazole for something other than Bryopsis and wonder why GHA/turf/bubble algae comes back after you stop using Flucon, this is the reason. The poll is for Bryopsis algae not GHA/turf algae/Bubble algae or any other algae.People are killing other forms of algae with Flucon but if/when it comes back after they stop using it,they think that the treatment didn't work and vote no but it did work,they just removed the meds and sent their tank back to the same conditions as before the treatment.Once you perform water changes and remove the meds,you'll have to address the problems that you have in your tank that allowed GHA/turf/bubble algae to grow to start with.


Continuous Low Dose Usage

We've got systems that are running on a continuous 5-20%(depending on nutrient levels) of the original dosage of Fluconazole. These systems were treated with the orginal dose(20mg/gal) for the first 3-6 weeks(depending on amount/type of algae). There were a few tanks(out of over 30 tanks)that were treated twice from being covered in GHA. Bryopsis died in the first few weeks in each system that had it(or at least all that we could visually see).
After the 3-6 weeks we performed a 20% water change with an additional 20% water change the following week. We then dosed most of the tanks with 10%(2mg/gal) of the original dosage except for some higher nutrient systems that we dosed 20%(4mg/gal).We did have a couple ULNS that we dosed with .5mg/gal with varying results. (it's hard to match every single factor in these tanks)So what we decided was to go with 1-2mg/gal for the ULNS.Once a month we perform a 20% water change and replace the 20% flucon dose.As I've said,we have some systems that haven't had a water change in months.We'll have more details about that later.
So in all we ran 20mg/gal to kill the algae then 1-4mg/gal to to keep any GHA from returning.

Please read the Frequently Asked Questions(FAQs) located right after the pictures before you treat your tank.It should answer most of your questions and help you avoid some mistakes.


Fluconazole can be used as an antifungal med for fish and I haven't seen any adverse reactions from using it, but I just don't want anyone to come back and say that they killed their fish/corals or inverts and blame me. This was not my discovery as I am just following what some others have already done. If you try this it is at your own risk and don't shoot the messenger. :)


Okay so like I have said in another Fluconazole thread,I always inspect and QT everything before it goes into my tank. I had several frags in qt for a few weeks and all seamed fine. Before transferring them to my DT I brushed off what looked like regular green surface algae and thought nothing of it.Well after about a month all three frags had a healthy helping of Bryopsis growing on them.
I've had to deal with this years ago so I know what kind of a struggle it can be. I did not want to just sit around and hope this cleared itself up because I knew this could get really bad.I had a tank full of Bryopsis years ago and tried everything I could to get rid of it and it just kept spreading everywhere.
Finally after gallons and gallons (system was almost 400gls)of Kent Tech M I was able to melt the Bryopsis away but it was no picnic.

Now, after learning that Kent Tech M has changed and doesn't work anymore or is hit or miss now,I read about some people having success against Bryopsis using Vibrant.I tried Vibrant for a couple of months and it did damage the Bryopsis fern/fan leaves but it wouldn't kill it off completely. I know people say to just give it more time but let me show you what can happen when you give Bryopsis time in your tank.(BTW I'm not knocking Vibrant or @UWC I think he has been a stand up guy on this forum and some people have had great success using their products)

They did not call me the Bryopsis King for no reason........

IMG_2539_zpstlsj2jqx.jpg


It was like this across the entire tank. Notice for you tang lovers out there that mine had no interest what so ever in eating any of the Bryopsis.If they would have kept the rocks picked clean this would not have reached being the forest that you see.I have more pics but it's ugly and I think you get the picture.As you can see,this would be my reason for NOT wanting to wait too long on this.

Anyway this brings me up to using Fluconazole. After searching the good ole web I found that some people(some over seas) were using Fluconazole in a one time dose to kill off Byropsis. At first I thought that this was too good to be true.I mean most people were saying that their tanks were Bryopsis free in about 10-15 days give or take a few days. Then they started posting before and after pics and also saying that they had not lost any fish or corals!! OMG sign me up! I thought. Well after doing a little more research I found out that Fluconazole can be used to treat infections/diseases in fish and that the dosage I would need to use was considered somewhat "safe" for the fish so I placed an order..

FishFlucon_zpsnanbm9t0.jpg


There were two different dosages that were being used. One was 9mg/L and the other was 150mg/30L which is 5mg/L. I have 200 gallons of total water volume in this system which is 757L. So 757L x 9mg/L would be a dose of 6813mg. 757L x 5mg/L would be a dose of 3785mg.
I went with 4000mg so it was 20mg per gallon.
Everyone was seeing their results when using the lower dose so I went with the lower dose.

*Also note that if I were using Fluconazole to treat my fish for infections I would need to dose this same amount every 24hrs for no less than 5 days but not more than 10 days.

This made me feel somewhat better about using it because this would be a one time dose and not building up 5-10 times as much in my aquarium over the course of 5-10 days.

So let the battle begin!!

Before I dosed the tank I turned off my actinic lighting,changed my filter socks from 200 micron to mesh filter socks,turned off the UV channels on my Radions,removed my GFO/GAC filters and removed my skimmer cup.

I emptied 20 of the 200mg capsule in a cup of tank water and stirred for a minute or two.(throw away the empty capsules) Not all of the medication dissolved but that's okay. I then poured the entire cup in my DT in front of a powerhead.
Cloudiness went away after about an hour. Fish,corals and inverts didn't seem to notice any change at all.

I apologize in advance for my blurry pics as photography is not my strong suit.

Edit: I know some people don't like reading through entire threads and just want to see the results so I'll keep this first post updated with all the pics.

Before the treatment started...
IMG_3216202_zpscoiwvocv.jpg


Day 1
IMG_322520copy_zpsoguugcqp.jpg


Day 2
IMG_3237_zpsqvej9tkm.jpg


Day 3
Day20320of20treatment_zpsyl1a99o5.jpg


Day 4
Day204_zpsgqll3qao.jpg


Day 5
Day520of20treatment_zpsbmaa0wjk.jpg


Day 6
Day620of20treatment_zpsbjmmjjtr.jpg


Day 7
Day720of20treatment_zps84kdz4dh.jpg


Day 8
Day820of20treatment_zps7aexqmnm.jpg


Day 9
Day920of20treatment_zpsalecznd5.jpg


Day 10
Day1020of20treatment_zps8edzv8zw.jpg


8 Months later and still no Bryopsis....
IMG_3509_zps6iq3f3qf.jpg


A big thank you to @stevo01 for his help on the FAQ for this thread.

Frequently Asked Questions (FAQs)

****This treatment seems to work best in well lit areas of the tank. Some people are noticing quicker results by adding light to the shaded areas of their tank.*****

Q: Will Fluconazole kill Bryopsis?
A: YES. Fluconazole will kill Bryopsis. There have been a couple of strains that seems to take longer to kill but if you have Bryopsis,it will kill it.It has also killed most forms of GHA although GHA takes longer to kill. Some tanks have needed another treatment to kill all of the GHA.Keep in mind that GHA can/will return in your system over time as you perform water changes and remove the Fluconazole. GHA shows up any time the conditions are right for its growth.This does not mean the treatment didn't work,only that the conditions were right for its return. Bryopsis however won't return in your system unless you didn't kill all of the Bryopsis cells during treatment or you reintroduce it into your tank through frags etc.


Q: How does Fluconazole work?
A: Fluconazole blocks the enzymatic pathway for the production of ergosterol. Ergosterol is essential for maintaining the cell wall integrity of plants. Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells.

Q: Will Fluconazole kill anything else in my system?
A: So far Fluconazole has not killed anything other than bryopsis and GHA. Everything and I mean EVERYTHING else is unaffected.

Q: Where do I get Fluconazole?
A: There are many sources online.You can search for Fish Fluconazole and find it.

Q: How much Fluconazole do I use?
A: The suggested dose is one SINGLE dose in the amount of 20mg per gallon of water. There are reefers who are experimenting with using 10mg per gallon right now, but none with completing the 1st "round".

Q: Do I do a WC before treatment?
A: Yes. It would be a good idea as the treatment is for 14-21 days(some GHA can take around 4 weeks) and expect an increase in nutrients.

Q: How do I prepare the the medication?
A: I have noticed with the capsules it is very tough opening them without crushing the capsule. This is what I did. Use a razor blade and cut off the rounded end of the large outer half of the capsule. Then you can very easily pour the contents out into a glass of RODI water or tank water. The amount of water doesnt matter, but make it enough to be able to mix the med up. The med isnt very soluble, but mix it up best you can. Preferably dose at night when fish are asleep. Then pour the entire dose into the DT, or sump. Some have put it into their sump socks. I dosed directly into the DT.

Q: How long is the treatment?
A: 14-21 days.Some GHA may take a little longer.Longer treatments have been run without any problems so if you want to continue your treatment past the 3 weeks it will be fine.We have tanks continuously running on a low dose of Fluconazole for a year now with no ill effects.

Q: Do I remove my carbon?
A: Yes.

Q: Do I remove my skimmer cup?
A: Its suggested for at least the first few days if not the entire treatment remove your cup. If you pull your cup you may continue to run the skimmer, or turn the skimmer down as to not allow the skim to enter the cup. You do not want to remove the med.

Q: Do I take my ATS offline?
A: Yes. Completely sanitize it, and reintroduce it after all the bryopsis is 100% gone.

Q: Do I take my bio reactor offline?
A: No.

Q: Do I take my GFO offline?
A: No GFO will not remove the meds.It will also help to remove the po4 from dying algae.

Q: Do I continue to dose H2O2?
A: Yes. It will not interact with this med.

Q: Do I continue to dose Vibrant?
A: Yes. This SHOULD not interact this med. It may help to dose Vibrant as it will assist in NO3 export.

Q: Do I continue to dose colors, alk, calcium, and magnesium?
A: Yes.

Q: Should I change my lighting?
A: No.

Q: If I take my carbon reactor, or any other equipment off line/out of the tank, do I just put them back into the system after treatment?
A: No. Do not reintroduce the algae. It would be best to sterilize any equipment and throw away old media for reactors.

Q: Is it ok to take out my chaeto, or other algae's then put back after treatment?
A: No. this may reintroduce the algae. Leave the macros in the tank.

Q: Do I take my carbon reactor offline?
A: Yes.

Q:Should I stop using Purigen during treatment?
A:Yes.

Q: Do I take my UV Sterilizer offline?
A: No. At first it was thought that the UV would break down the meds but further testing has shown that it doesn't seem to effect the treatment enough to remove it.

Q: Do I do a WC during treatment?
A: No. Unless it cannot be avoided and a WC needs to be done to save life.If you perform a wc then replace the meds with the fresh saltwater.

Q: Will Fluconazole kill my chaetomorpha or other beneficial maco's?
A: Some users have reported some macro algae loss during the treatment but most have not.We are not seeing any wide spread death in macros so it's more of a judgement call on your part.

Q: Will Fluconazole kill the parasitic algae known to burrow through LPS corals?
A: This is currently being researched.

Q: What other nuisance algae's will be killed by Fluconazole?
A: Fluconazole kills the green algae Derbesia also known as GHA. It seems that GHA takes longer to kill than the bryopsis but it still dies. It does not kill Bubble algae.

Q: When do I do a WC?
A: After treatment has completed you will go back to your normal running system. Do a WC as your NO3/PO4 levels may be high from a lot of dead algae.

NCreefguy and Stevo



This treatment has been a huge success.For so many years we have had to deal with this terrible algae. Well now we can finally say that beating Bryopsis is a reality. No more tearing down your tanks. No more endless hours of pulling and picking at this mess. Fluconazole has made the eradication of Bryopsis from our tanks quick,easy and painless.Please let everyone you know in the reefing community about this treatment. The more people who know,the better.

Thank you to everyone who has been and continues to help and contribute in the thread. R2R has the best reefing community around!!!

Special Note:
@Jose Mayo MD is the person from Brazil that discovered the actions of Fluconazole on algae. His discovery is the reason there are so many happy reefers today and will continue to be. Here are a couple of posts explaining his findings.
https://www.reef2reef.com/threads/b...sing-fluconazole.285096/page-224#post-4205834

Thank you very much Mr. Mayo for your work,research and continued help with this treatment.You are a tremendous asset to the reefing community.


NCreefguy
I'm sorry... New Here.

Dosage was describe but it didn't mention to dose everyday for 14 to 21days, or dose ONCE for every 14days?
 

AustinJT

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Thank you so much...

They all said one thing "Treat for the course of 14days".
What kind of Course? Once a day course? Twice a day course? Interval Course? Daily Course?

Like Seachem Cuprimen, they also treated for a course of 14days but they made it specific to dose just ONCE.
But add on to advice to split the dosage in 50/50 and dose for 24hrs apart and to dose extra amount in order to maintain specific copper range within this 14days. But they made it very clear, to dose just ONCE within 14days.

It is very risky to dose any unorthodox treatment. I had my fun (Not really, when you're housed a $12,000 Mask Angelfish Pair amongst various Rare & Expensive deep water anthias) experimented with Levamisole to treat AEFW.

It surprises me as I read various threads regarding this algae topic and not a single person of any threads across various forums regarding this subject made it clear to Dose ONCE every 14-21days. They simply left out that part. And I carefully read many forums.

NOT A SINGLE PERSON MADE IT CLEAR.

How hard it be to phrase thing properly?
1. Recommend Dosage 20mg/L
2. Find proper dosage for you Tank's volume based on recommend dosage.
3. Dose correct amount, just ONCE and leave it for 14days or up to 21days and do a water change 10-20%.
4. If repeated dosage require, be sure do another water change before dosing again. And leave another 14-21days.
5. And repeat the steps, if necessary.

HOW HARD CAN IT BE TO PHRASE IT ALL CORRECTLY???

Also... I would like to ask one thing...
How many treatment do you repeat?
Does it affect any slugs at all? I have lots of Sea Lettuce Slug.

I had a great success with lab grade HP... the only issue it's killing my shrimps. But snail, slugs & crabs are fine.

Lettuce slugs been amazing except of getting sucked into waves and not eating any useless algae.
They seems to favors more of Macro or useful or ornamental algae instead. I actually feed them actual lettuce to keep them alive. And they seemed to leave all my algae alone. Stupid slugs. Adorable but kind of useless & stupid.

Again, thank you so much for clarifying....
 

taulgrl

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Curious if anyone noticed a negative effect on Dragon’s Breath macro algae. I’m on day 4 of Reeflux but moved the macro out of my sump because I didn’t want to lose it.

also, interesting effect Reeflux had on bryopsis… on day 2 my foxface all of a sudden (for first time) found it to be delicious and now on day 4 it is almost all gone from either disintegration or (mostly) foxface eating
 

AustinJT

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No idea on Dragon's Breath, not many people keeping Macro. But I do notice this... it doesn't work on red slime compare to HP. And not entire effectively against Hair Algae either.... I do notice some reduction but it's like 10 times slower than HP. Or maybe, my pills are not high grade? I got indian version, it's $5 per box = 20pills x 150mg.
There is a USA version that is $12.5 per pill and it's 150mg too. If using 40pills based on recommended dosage for tank, that's $500.

I found a Lab Grade HP that designed to clean medical tools. Works wonder. Issue is, you have to dose about $2-$3 (Per Day) depending on your tank size. Mine is roughly $3. So that's $90 a month.

If using my version of HP... it ravages all of algae within 4-5days. Oh... it's Arch-nemesis with Bubble Algae... it complete destroy it within a week...

But works wondrously... Except....

It kills Skunk Cleaners... Just the Skunk though... My Peppermint, Sally.... are Perfect.
I do notice some lost Urchin, Strawberry Conches and some starfish over time but I think it's more of "Cleanness".
Too clean... no algae to feed upon...

Ah.... my slugs are OK too... somehow... Green Lettuce are fine too.
 

Danny McElroy

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The Poll In This Thread is For Bryopsis Only not GHA,Turf,Bubble Algae or any other Algae

The 2 week treatment is for Bryopsis algae. For GHA,turf algae and bubble algae it may take as long as 4-6 weeks to kill.

GHA,turf algae,bubble algae are different than Bryopsis algae. Bryopsis algae will not return if you kill all of the Bryopsis cells unless you reintroduce it into your tank. The others can/will return once you stop treating your tank and perform water changes to remove the meds. Fluconazole doesn't change the conditions in your tank that allowed for the algae growth in the first place. Removing the meds just sends your tank back to the same conditons that you had before the treatment. If your using Fluconazole for something other than Bryopsis and wonder why GHA/turf/bubble algae comes back after you stop using Flucon, this is the reason. The poll is for Bryopsis algae not GHA/turf algae/Bubble algae or any other algae.People are killing other forms of algae with Flucon but if/when it comes back after they stop using it,they think that the treatment didn't work and vote no but it did work,they just removed the meds and sent their tank back to the same conditions as before the treatment.Once you perform water changes and remove the meds,you'll have to address the problems that you have in your tank that allowed GHA/turf/bubble algae to grow to start with.


Continuous Low Dose Usage

We've got systems that are running on a continuous 5-20%(depending on nutrient levels) of the original dosage of Fluconazole. These systems were treated with the orginal dose(20mg/gal) for the first 3-6 weeks(depending on amount/type of algae). There were a few tanks(out of over 30 tanks)that were treated twice from being covered in GHA. Bryopsis died in the first few weeks in each system that had it(or at least all that we could visually see).
After the 3-6 weeks we performed a 20% water change with an additional 20% water change the following week. We then dosed most of the tanks with 10%(2mg/gal) of the original dosage except for some higher nutrient systems that we dosed 20%(4mg/gal).We did have a couple ULNS that we dosed with .5mg/gal with varying results. (it's hard to match every single factor in these tanks)So what we decided was to go with 1-2mg/gal for the ULNS.Once a month we perform a 20% water change and replace the 20% flucon dose.As I've said,we have some systems that haven't had a water change in months.We'll have more details about that later.
So in all we ran 20mg/gal to kill the algae then 1-4mg/gal to to keep any GHA from returning.

Please read the Frequently Asked Questions(FAQs) located right after the pictures before you treat your tank.It should answer most of your questions and help you avoid some mistakes.


Fluconazole can be used as an antifungal med for fish and I haven't seen any adverse reactions from using it, but I just don't want anyone to come back and say that they killed their fish/corals or inverts and blame me. This was not my discovery as I am just following what some others have already done. If you try this it is at your own risk and don't shoot the messenger. :)


Okay so like I have said in another Fluconazole thread,I always inspect and QT everything before it goes into my tank. I had several frags in qt for a few weeks and all seamed fine. Before transferring them to my DT I brushed off what looked like regular green surface algae and thought nothing of it.Well after about a month all three frags had a healthy helping of Bryopsis growing on them.
I've had to deal with this years ago so I know what kind of a struggle it can be. I did not want to just sit around and hope this cleared itself up because I knew this could get really bad.I had a tank full of Bryopsis years ago and tried everything I could to get rid of it and it just kept spreading everywhere.
Finally after gallons and gallons (system was almost 400gls)of Kent Tech M I was able to melt the Bryopsis away but it was no picnic.

Now, after learning that Kent Tech M has changed and doesn't work anymore or is hit or miss now,I read about some people having success against Bryopsis using Vibrant.I tried Vibrant for a couple of months and it did damage the Bryopsis fern/fan leaves but it wouldn't kill it off completely. I know people say to just give it more time but let me show you what can happen when you give Bryopsis time in your tank.(BTW I'm not knocking Vibrant or @UWC I think he has been a stand up guy on this forum and some people have had great success using their products)

They did not call me the Bryopsis King for no reason........

IMG_2539_zpstlsj2jqx.jpg


It was like this across the entire tank. Notice for you tang lovers out there that mine had no interest what so ever in eating any of the Bryopsis.If they would have kept the rocks picked clean this would not have reached being the forest that you see.I have more pics but it's ugly and I think you get the picture.As you can see,this would be my reason for NOT wanting to wait too long on this.

Anyway this brings me up to using Fluconazole. After searching the good ole web I found that some people(some over seas) were using Fluconazole in a one time dose to kill off Byropsis. At first I thought that this was too good to be true.I mean most people were saying that their tanks were Bryopsis free in about 10-15 days give or take a few days. Then they started posting before and after pics and also saying that they had not lost any fish or corals!! OMG sign me up! I thought. Well after doing a little more research I found out that Fluconazole can be used to treat infections/diseases in fish and that the dosage I would need to use was considered somewhat "safe" for the fish so I placed an order..

FishFlucon_zpsnanbm9t0.jpg


There were two different dosages that were being used. One was 9mg/L and the other was 150mg/30L which is 5mg/L. I have 200 gallons of total water volume in this system which is 757L. So 757L x 9mg/L would be a dose of 6813mg. 757L x 5mg/L would be a dose of 3785mg.
I went with 4000mg so it was 20mg per gallon.
Everyone was seeing their results when using the lower dose so I went with the lower dose.

*Also note that if I were using Fluconazole to treat my fish for infections I would need to dose this same amount every 24hrs for no less than 5 days but not more than 10 days.

This made me feel somewhat better about using it because this would be a one time dose and not building up 5-10 times as much in my aquarium over the course of 5-10 days.

So let the battle begin!!

Before I dosed the tank I turned off my actinic lighting,changed my filter socks from 200 micron to mesh filter socks,turned off the UV channels on my Radions,removed my GFO/GAC filters and removed my skimmer cup.

I emptied 20 of the 200mg capsule in a cup of tank water and stirred for a minute or two.(throw away the empty capsules) Not all of the medication dissolved but that's okay. I then poured the entire cup in my DT in front of a powerhead.
Cloudiness went away after about an hour. Fish,corals and inverts didn't seem to notice any change at all.

I apologize in advance for my blurry pics as photography is not my strong suit.

Edit: I know some people don't like reading through entire threads and just want to see the results so I'll keep this first post updated with all the pics.

Before the treatment started...
IMG_3216202_zpscoiwvocv.jpg


Day 1
IMG_322520copy_zpsoguugcqp.jpg


Day 2
IMG_3237_zpsqvej9tkm.jpg


Day 3
Day20320of20treatment_zpsyl1a99o5.jpg


Day 4
Day204_zpsgqll3qao.jpg


Day 5
Day520of20treatment_zpsbmaa0wjk.jpg


Day 6
Day620of20treatment_zpsbjmmjjtr.jpg


Day 7
Day720of20treatment_zps84kdz4dh.jpg


Day 8
Day820of20treatment_zps7aexqmnm.jpg


Day 9
Day920of20treatment_zpsalecznd5.jpg


Day 10
Day1020of20treatment_zps8edzv8zw.jpg


8 Months later and still no Bryopsis....
IMG_3509_zps6iq3f3qf.jpg


A big thank you to @stevo01 for his help on the FAQ for this thread.

Frequently Asked Questions (FAQs)

****This treatment seems to work best in well lit areas of the tank. Some people are noticing quicker results by adding light to the shaded areas of their tank.*****

Q: Will Fluconazole kill Bryopsis?
A: YES. Fluconazole will kill Bryopsis. There have been a couple of strains that seems to take longer to kill but if you have Bryopsis,it will kill it.It has also killed most forms of GHA although GHA takes longer to kill. Some tanks have needed another treatment to kill all of the GHA.Keep in mind that GHA can/will return in your system over time as you perform water changes and remove the Fluconazole. GHA shows up any time the conditions are right for its growth.This does not mean the treatment didn't work,only that the conditions were right for its return. Bryopsis however won't return in your system unless you didn't kill all of the Bryopsis cells during treatment or you reintroduce it into your tank through frags etc.


Q: How does Fluconazole work?
A: Fluconazole blocks the enzymatic pathway for the production of ergosterol. Ergosterol is essential for maintaining the cell wall integrity of plants. Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells.

Q: Will Fluconazole kill anything else in my system?
A: So far Fluconazole has not killed anything other than bryopsis and GHA. Everything and I mean EVERYTHING else is unaffected.

Q: Where do I get Fluconazole?
A: There are many sources online.You can search for Fish Fluconazole and find it.

Q: How much Fluconazole do I use?
A: The suggested dose is one SINGLE dose in the amount of 20mg per gallon of water. There are reefers who are experimenting with using 10mg per gallon right now, but none with completing the 1st "round".

Q: Do I do a WC before treatment?
A: Yes. It would be a good idea as the treatment is for 14-21 days(some GHA can take around 4 weeks) and expect an increase in nutrients.

Q: How do I prepare the the medication?
A: I have noticed with the capsules it is very tough opening them without crushing the capsule. This is what I did. Use a razor blade and cut off the rounded end of the large outer half of the capsule. Then you can very easily pour the contents out into a glass of RODI water or tank water. The amount of water doesnt matter, but make it enough to be able to mix the med up. The med isnt very soluble, but mix it up best you can. Preferably dose at night when fish are asleep. Then pour the entire dose into the DT, or sump. Some have put it into their sump socks. I dosed directly into the DT.

Q: How long is the treatment?
A: 14-21 days.Some GHA may take a little longer.Longer treatments have been run without any problems so if you want to continue your treatment past the 3 weeks it will be fine.We have tanks continuously running on a low dose of Fluconazole for a year now with no ill effects.

Q: Do I remove my carbon?
A: Yes.

Q: Do I remove my skimmer cup?
A: Its suggested for at least the first few days if not the entire treatment remove your cup. If you pull your cup you may continue to run the skimmer, or turn the skimmer down as to not allow the skim to enter the cup. You do not want to remove the med.

Q: Do I take my ATS offline?
A: Yes. Completely sanitize it, and reintroduce it after all the bryopsis is 100% gone.

Q: Do I take my bio reactor offline?
A: No.

Q: Do I take my GFO offline?
A: No GFO will not remove the meds.It will also help to remove the po4 from dying algae.

Q: Do I continue to dose H2O2?
A: Yes. It will not interact with this med.

Q: Do I continue to dose Vibrant?
A: Yes. This SHOULD not interact this med. It may help to dose Vibrant as it will assist in NO3 export.

Q: Do I continue to dose colors, alk, calcium, and magnesium?
A: Yes.

Q: Should I change my lighting?
A: No.

Q: If I take my carbon reactor, or any other equipment off line/out of the tank, do I just put them back into the system after treatment?
A: No. Do not reintroduce the algae. It would be best to sterilize any equipment and throw away old media for reactors.

Q: Is it ok to take out my chaeto, or other algae's then put back after treatment?
A: No. this may reintroduce the algae. Leave the macros in the tank.

Q: Do I take my carbon reactor offline?
A: Yes.

Q:Should I stop using Purigen during treatment?
A:Yes.

Q: Do I take my UV Sterilizer offline?
A: No. At first it was thought that the UV would break down the meds but further testing has shown that it doesn't seem to effect the treatment enough to remove it.

Q: Do I do a WC during treatment?
A: No. Unless it cannot be avoided and a WC needs to be done to save life.If you perform a wc then replace the meds with the fresh saltwater.

Q: Will Fluconazole kill my chaetomorpha or other beneficial maco's?
A: Some users have reported some macro algae loss during the treatment but most have not.We are not seeing any wide spread death in macros so it's more of a judgement call on your part.

Q: Will Fluconazole kill the parasitic algae known to burrow through LPS corals?
A: This is currently being researched.

Q: What other nuisance algae's will be killed by Fluconazole?
A: Fluconazole kills the green algae Derbesia also known as GHA. It seems that GHA takes longer to kill than the bryopsis but it still dies. It does not kill Bubble algae.

Q: When do I do a WC?
A: After treatment has completed you will go back to your normal running system. Do a WC as your NO3/PO4 levels may be high from a lot of dead algae.

NCreefguy and Stevo



This treatment has been a huge success.For so many years we have had to deal with this terrible algae. Well now we can finally say that beating Bryopsis is a reality. No more tearing down your tanks. No more endless hours of pulling and picking at this mess. Fluconazole has made the eradication of Bryopsis from our tanks quick,easy and painless.Please let everyone you know in the reefing community about this treatment. The more people who know,the better.

Thank you to everyone who has been and continues to help and contribute in the thread. R2R has the best reefing community around!!!

Special Note:
@Jose Mayo MD is the person from Brazil that discovered the actions of Fluconazole on algae. His discovery is the reason there are so many happy reefers today and will continue to be. Here are a couple of posts explaining his findings.
https://www.reef2reef.com/threads/b...sing-fluconazole.285096/page-224#post-4205834

Thank you very much Mr. Mayo for your work,research and continued help with this treatment.You are a tremendous asset to the reefing community.


NCreefguy
Excellent post, thank you for sharing!!!
 

taulgrl

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No idea on Dragon's Breath, not many people keeping Macro. But I do notice this... it doesn't work on red slime compare to HP. And not entire effectively against Hair Algae either.... I do notice some reduction but it's like 10 times slower than HP. Or maybe, my pills are not high grade? I got indian version, it's $5 per box = 20pills x 150mg.
There is a USA version that is $12.5 per pill and it's 150mg too. If using 40pills based on recommended dosage for tank, that's $500.

I found a Lab Grade HP that designed to clean medical tools. Works wonder. Issue is, you have to dose about $2-$3 (Per Day) depending on your tank size. Mine is roughly $3. So that's $90 a month.

If using my version of HP... it ravages all of algae within 4-5days. Oh... it's Arch-nemesis with Bubble Algae... it complete destroy it within a week...

But works wondrously... Except....

It kills Skunk Cleaners... Just the Skunk though... My Peppermint, Sally.... are Perfect.
I do notice some lost Urchin, Strawberry Conches and some starfish over time but I think it's more of "Cleanness".
Too clean... no algae to feed upon...

Ah.... my slugs are OK too... somehow... Green Lettuce are fine too.
I put the Dragons Breath back into the sump about a week after treating tank. I had a little die off after that , but it mostly survived. It does seem a bit sensitive to the flux and I would probably remove again if I have to treat again.
 

Techno27

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Hi, I have a serius Algea problem in my tank. I want to try the Fluconazole. But here in Québec, Canada one pill is 20$ca. Somone can get a bottle of 100 for me and ship it?
 

mfinn

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Hi, I have a serius Algea problem in my tank. I want to try the Fluconazole. But here in Québec, Canada one pill is 20$ca. Somone can get a bottle of 100 for me and ship it?
I'm not sure, but I would bet Canadian customs would take issue with that.
 

Techno27

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I'm not sure, but I would bet Canadian customs would take issue with that.
No prescription needed for Fluconazole in Canada. But the price !!! Realy high. It is not a illegal substance.

 

The_Macro_Lady

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Curious if anyone noticed a negative effect on Dragon’s Breath macro algae. I’m on day 4 of Reeflux but moved the macro out of my sump because I didn’t want to lose it.

also, interesting effect Reeflux had on bryopsis… on day 2 my foxface all of a sudden (for first time) found it to be delicious and now on day 4 it is almost all gone from either disintegration or (mostly) foxface eating
Fluconazole will kill off some of the macro algaes. I lost many species of caulerpa and Halymenia (dragons breath). I’ve learned to appreciate bryopsis as a “free” macro algae
 

taricha

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Photodegradation of the azole fungicide fluconazole in aqueous solution under UV-254: Kinetics, mechanistic investigations and toxicity evaluation ( https://core.ac.uk/download/pdf/71730415.pdf )
Thanks for this. My sense is that we think fluconazole would last for an extended time in our systems (weeks)?
Looks like the paper was suggesting the same thing in wastewater treatment.
Is that our expectation?
 

Jose Mayo

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Obrigado por isso. Minha impressão é que achamos que o fluconazol duraria muito tempo em nossos sistemas (semanas)?
Parece que o jornal estava sugerindo a mesma coisa no tratamento de águas residuais.
Essa é a nossa expectativa?
Sim, o fluconazol pode persistir durante muito tempo, seja no aquário ou nas águas residuais. O carvão ativado pode retirarlo rapidamente do aquário, mas não do meioambiente... É um ponto a mais a se pensar quando se usa o produto
 

taricha

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"Yes, fluconazole can persist for a long time, either in the aquarium or in wastewater. Activated charcoal can quickly remove it from the aquarium, but not from the environment... It is another point to think about when using the product"
Thanks @Jose Mayo
 

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