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My maintenance dose in my 240g tank daily is 20mls. your buddy may have a huge skimmer on his system, or a fuge with macro. But got lucky only having to dose 4mls in a 500g, thats just not normal.I didnt think to do that before I started! A true scientist would have done that ! But I can say, I have been doing it for over 2 months and I have worked my way up to 6.5 ml's and noticed very little if any changes other than more, stinky skimmate! I know people that have done it before love it but I gotta admit I am losing confidence. I had a friend that had a 500 and ended up with a 4 ml maintenance dose. I guess I was hoping for that. Maybe wishfu thinking but im not sure how comfortable I am putting a 5-6 ml maintenance dose in a 210. We will see how it goes but I wont go up any more than 10 ml's.