Of course you can. Both run the same. Just different chemicals (Iron VS Aluminum) . GFO Clumps more from what I hear. Phosguard is beads.I have a BRS dual chambered GFO and Carbon reactor. Can I just pull out the GFO and replace it with Phosguard or does it have to be run differently?
Both should be set to flows, just a notch below tumbling.
I might also look into Seachem PHOSbond. It's GFO and PhosGuard in same bead form . NOT CHEAP, and probably more aggressive than I want.