It's really not my area of expertise in the slightest. It seems like a logical argument that getting higher concentrations of the medicine to the source will have a better effect. But are infrequent higher doses better than sustained lower ones? I have not a clue. Based on the evidence here, it would seem to suggest that feeding combined with Prazipro was insufficient at saving this fish, but that doesn't mean treating the water would have saved it. Sigh...One reason i always shied away from feeding meds. You never know what amount the fish have actually ingested. I always stick to medicating the water in suggested doses.