fluconazole x bryopsis

[jason2459]

This is cool and all

"This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols.[20] Fluconazole is primarily fungistatic; however, it may be fungicidal against certain organisms in a dose-dependent manner, specifically Cryptococcus.[29]"

But I its ability to disrupt this

"Fluconazole is an inhibitor of the human cytochrome P450 system, particularly the isozyme CYP2C19 (CYP3A4 and CYP2C9 to lesser extent) [27]"

I find most interesting. The cytochrome P450 system is not unique to humans or fungi. This also could disrupt the uptake of a vital element for bryopsis to live, Fe. Just a guess.

https://en.m.wikipedia.org/wiki/Cytochrome_P450


So, be warned if that's it it could effect more then bryopsis like many other microorganisms.

Like this interesting fact
"Cytochrome P450 eryF (CYP107A1) originally from the actinomycete bacterium Saccharopolyspora erythraea is responsible for the biosynthesis of the antibiotic erythromycin by C6-hydroxylation of the macrolide 6-deoxyerythronolide B."


Or

"
Plants
Plant cytochrome P450s are involved in a wide range of biosynthetic reactions and target a diverse range of biomolecules. These reactions lead to various fatty acid conjugates, plant hormones, secondary metabolites, lignins, and a variety of defensive compounds.[44] Plant genome annotations suggest that Cytochrome P450 genes make up as much as 1% of the plant genes. The number and diversity of P450 genes is responsible, in part, for the multitude of bioactive compounds.[45]"

 

[FDAWG]

Do acros approve this treatment?

 

[Rick.45cal]

I'm not jumping in feet first, just gonna keep it in my back pocket for the moment.

 

[Sabellafella]

This is cool and all

"This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols.[20] Fluconazole is primarily fungistatic; however, it may be fungicidal against certain organisms in a dose-dependent manner, specifically Cryptococcus.[29]"

But I its ability to disrupt this

"Fluconazole is an inhibitor of the human cytochrome P450 system, particularly the isozyme CYP2C19 (CYP3A4 and CYP2C9 to lesser extent) [27]"

I find most interesting. The cytochrome P450 system is not unique to humans or fungi. This also could disrupt the uptake of a vital element for bryopsis to live, Fe. Just a guess.

https://en.m.wikipedia.org/wiki/Cytochrome_P450


So, be warned if that's it it could effect more then bryopsis like many other microorganisms.

Like this interesting fact
"Cytochrome P450 eryF (CYP107A1) originally from the actinomycete bacterium Saccharopolyspora erythraea is responsible for the biosynthesis of the antibiotic erythromycin by C6-hydroxylation of the macrolide 6-deoxyerythronolide B."


Or

"
Plants
Plant cytochrome P450s are involved in a wide range of biosynthetic reactions and target a diverse range of biomolecules. These reactions lead to various fatty acid conjugates, plant hormones, secondary metabolites, lignins, and a variety of defensive compounds.[44] Plant genome annotations suggest that Cytochrome P450 genes make up as much as 1% of the plant genes. The number and diversity of P450 genes is responsible, in part, for the multitude of bioactive compounds.[45]"

Wow unbelievable stuff, great work. So in all reality, its a possible risk. The few people that have used the medicine, saw a complete 100% die off just from one treatment. Only took about a week or 2 before they started going about their normal maintenance routine. Is their any sort of half life on this stuff?

 

[Sabellafella]

Do acros approve this treatment?

Too soon enuff to say, every trial so far proved their fine,fish,lps,inverts, even cyano and gha that where all fine.I heard the ph stayed stable as well but then again its only ben about a month or two.

 

[redfishbluefish]

I definitely think it's proceed with caution....however, initial trials have been very promising. After approximately two weeks you begin water changes and adding carbon to remove the drug.

 

[saltyfilmfolks]

Following along.

 

[Bassett22]

Ive got a 29 gallon I just started up and cycled with a MASSIVE outbreak right now. Since the tank is young and only has a couple fish and corals I was planning on ripping it all apart and scrubbing the tank in bleach and starting it over. Where can I get this medicine? Id be happy to try it before I start over.

 

[redfishbluefish]

HERE's one place you can purchase.

 

[twilliard]

HERE's one place you can purchase.

I did a test order to see if they are for real.

 

[redfishbluefish]

I did a test order to see if they are for real.

They are real! FYI, you want to open up the capsules and empty the drug out of the capsules....don't put the capsules in your tank!

 

[twilliard]

They are real! FYI, you want to open up the capsules and empty the drug out of the capsules....don't put the capsules in your tank!

Thanks Paul! This should be interesting to work with.

 

[Sabellafella]

Ive got a 29 gallon I just started up and cycled with a MASSIVE outbreak right now. Since the tank is young and only has a couple fish and corals I was planning on ripping it all apart and scrubbing the tank in bleach and starting it over. Where can I get this medicine? Id be happy to try it before I start over.

If theres a half life on the fish flucon id try it. The dose is pretty heavy, maybe get some carbon also.

 

[NCreefguy]

I did a test order to see if they are for real.

My order from them came in today.

 

[Sabellafella]

My order from them came in today.

You knew about this?

 

[twilliard]

My order from them came in today.

I will be all over this!

 

[NCreefguy]

You knew about this?

I've been reading about this for a little while.

I am usually pretty thorough at inspecting all my frags/fish and always qt everything no matter what but a few frags that had what looked like regular green surface algae that I brushed clean(or so I thought) ended up coming back a month later and waving its ugly fern fans at me. I was able to remove one of the frags and re-frag it without too much destruction but the other two are not in ideal places for removal. I've dealt with Bryopsis in the past and it's a real pain to say the least. I've always been nervous to remove new frags from their plugs (especially high end ones)but I'll never put another coral in my tank without removing it first.

I will be dosing 4000mgs in my system while removing my gfo/gac and skimmer cup.

This is not the only thing that I'm dealing with at the moment as I have been slowly removing my DSB that has been in my tank now for around 14 years but that's an entirely different thread lol.

 

[Sabellafella]

I've been reading about this for a little while.

I am usually pretty thorough at inspecting all my frags/fish and always qt everything no matter what but a few frags that had what looked like regular green surface algae that I brushed clean(or so I thought) ended up coming back a month later and waving its ugly fern fans at me. I was able to remove one of the frags and re-frag it without too much destruction but the other two are not in ideal places for removal. I've dealt with Bryopsis in the past and it's a real pain to say the least. I've always been nervous to remove new frags from their plugs (especially high end ones)but I'll never put another coral in my tank without removing it first.

I will be dosing 4000mgs in my system while removing my gfo/gac and skimmer cup.

This is not the only thing that I'm dealing with at the moment as I have been slowly removing my DSB that has been in my tank now for around 14 years but that's an entirely different thread lol.

Amazing, hope everything turns out great! Let us know how it works

 

[kschweer]

Here are the pictures @redfishbluefish was having a hard time uploading.

Before:

Day 10

Here's the thread if anyone is interested:
http://www.njreefers.org/threads/fluconazole.94821/

 

[Sabellafella]

Here are the pictures @redfishbluefish was having a hard time uploading.

Before:

Day 10

Here's the thread if anyone is interested:
http://www.njreefers.org/threads/fluconazole.94821/

Thanks kev